Molecular mechanisms of LKB1 induced cell cycle arrest
نویسندگان
چکیده
منابع مشابه
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متن کاملGrowth suppression by Lkb1 is mediated by a G(1) cell cycle arrest.
Germ-line mutations of LKB1 (STK11) lead to Peutz-Jeghers syndrome characterized by gastrointestinal polyps and cancer of different organ systems. The mutations lead to loss or severe impairment of Lkb1 serine/threonine kinase activity. Therefore LKB1 has been implicated as a tumor suppressor gene, but only a few mutations in the coding exons of LKB1 have been detected in sporadic tumors. Here,...
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ژورنال
عنوان ژورنال: Thoracic Cancer
سال: 2013
ISSN: 1759-7706
DOI: 10.1111/1759-7714.12003